N-[12-(1H-imidazol-1-yl)dodecanoyl]-L-leucine

N-[12-(1H-imidazol-1-yl)dodecanoyl]-L-leucine is a synthetic small molecule belonging to the class of leucine derivatives, specifically an L-peptide linking compound. It features a dodecanoic acid chain with an imidazole group at the omega position, conjugated to L-leucine. This compound has been studied as an inhibitor of cytochrome P450 BM3 (CYP102A1), a bacterial P450 enzyme from Bacillus megaterium. Structural studies show it binds to the heme domain of P450BM3 and acts as a more potent inhibitor than parent omega-imidazolyl fatty acids, likely due to its unique interaction with the enzyme's active site. Its pharmacological action in humans is unknown and it has not been approved for any clinical use[6][9][5].

Other names

N-(12-(1H-imidazol-1-yl)dodecanoyl)-L-leucine(2S)-2-(12-(1H-imidazol-1-yl)dodecanamido)-4-methylpentanoic acid(2S)-2-[12-(1H-imidazol-1-yl)dodecanamido]-4-methylpentanoic acidN-[12-(1h-Imidazol-1-Yl)dodecanoyl]-L-LeucineN-[12-(Imidazolyl)-dodecanoyl]-L-leucine