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N-acetyl cysteine + alpha lipoic acid + liposomal glutathione (Jiangsu Hengrui Pharmaceuticals Co., Ltd.)
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
N-acetyl cysteine + alpha lipoic acid + liposomal glutathione is an antioxidant combination therapy investigated for its potential to ameliorate oxidative stress-induced metabolic dysfunction in type 2 diabetes mellitus (T2DM). The combination leverages three distinct pathways: N-acetyl cysteine (NAC) provides the rate-limiting substrate (cysteine) for endogenous glutathione synthesis; alpha-lipoic acid (ALA) acts as a potent, amphipathic antioxidant that regenerates other antioxidants like vitamins C and E and increases intracellular glutathione; and liposomal glutathione provides a direct, bioavailable source of the tripeptide to bypass degradation in the digestive tract. By reducing the burden of reactive oxygen species (ROS), the therapy aims to protect pancreatic beta-cells and improve peripheral insulin sensitivity. While the provided context links this combination to Jiangsu HengRui Medicine Co., Ltd., it is primarily recognized in academic clinical trials (e.g., NCT01470781) exploring the role of oxidative stress in diabetic pathophysiology.
- Brand names
- Biogen Liposomal Glutathione
- Other names
- NAC + ALA + GSHN-acetylcysteine + alpha-lipoic acid + glutathione
02
Targets
GSH (Glutathione)
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