Drug intelligence / Profile preview

N-acetyl cysteine + alpha lipoic acid + liposomal glutathione + Novartis influenza vaccine

Development stage
Unknown
Lead developer
GSK
Modality
Peptides, Small Molecules, Vaccines & Immunotherapeutics
Administration
Intramuscular, Oral
01

Overview

This combination therapy consists of three antioxidant compounds—**N-acetyl cysteine (NAC)**, **alpha lipoic acid (ALA)**, and **liposomal glutathione**—administered in conjunction with a seasonal influenza vaccine developed by **Novartis Vaccines** (such as the MF59-adjuvanted **Fluad** or the unadjuvanted **Agrippal**). NAC is a thiol-containing derivative of the amino acid L-cysteine that serves as a rate-limiting precursor for the synthesis of glutathione, the body's primary endogenous antioxidant. Alpha lipoic acid is a potent metabolic antioxidant and enzymatic cofactor that helps regenerate other antioxidants like Vitamin C and E. Liposomal glutathione is a specialized formulation designed to improve the oral bioavailability of the tripeptide glutathione. The Novartis influenza vaccine component refers to the subunit vaccines evaluated in clinical trials like the **V70P5** extension study, which assessed the immunogenicity and safety of adjuvanted versus non-adjuvanted formulations in pediatric populations. This combination is typically investigated for its potential to modulate the immune response, reduce oxidative stress associated with viral infection, or enhance the safety profile of the immunization.

Brand names
FluadAgrippal
Other names
N-acetyl cysteine + alpha lipoic acid + liposomal glutathione-Novartis Vaccines-influenzaAntioxidant Stack + Novartis Influenza Vaccine
02

Targets

HA (Hemagglutinin)

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