Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
N-acetylcysteine + colistin
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
N-acetylcysteine + colistin is a synergistic pharmacological combination that demonstrates enhanced antibacterial and antibiofilm activity against multidrug-resistant gram-negative bacteria. N-acetylcysteine (NAC) is a mucolytic agent with antioxidant properties, while colistin (polymyxin E) is a polymyxin antibiotic. When combined, NAC potentiates colistin's activity against bacterial biofilms and can potentially reverse colistin resistance in certain bacterial strains. The combination is particularly effective against Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia, including biofilm-associated infections. Additionally, NAC may help prevent colistin-induced nephrotoxicity, a common side effect of colistin therapy.
- Other names
- NAC + colistinN-acetyl cysteine + colistinNAC-colistin combination
Beyond the preview
Go deeper on N-acetylcysteine + colistin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on N-acetylcysteine + colistin.