N-acetylcysteine + lipid emulsion + heparin

This is a combination therapy consisting of three agents: - **N-acetylcysteine (NAC):** A thiol-containing small molecule with antioxidant properties, widely used as an antidote for acetaminophen poisoning and in various conditions involving oxidative stress. NAC acts primarily by replenishing intracellular glutathione, neutralizing reactive oxygen species, and modulating redox-sensitive signaling pathways. It also inhibits arachidonate 5-lipoxygenase-derived toxic lipids and can reduce the activity of vitamin K-dependent coagulation factors by interfering with disulfide bridges in glycoproteins[2][3]. - **Lipid emulsion:** An intravenous fat emulsion used as an energy source in parenteral nutrition or as an antidote for certain drug toxicities (notably local anesthetic toxicity). Lipid emulsions act by providing alternative substrates for cellular metabolism and sequestering lipophilic toxins from target tissues ("lipid sink" effect)[4][6]. - **Heparin:** An anticoagulant that potentiates the activity of antithrombin III, thereby inhibiting thrombin and factor Xa to prevent clot formation. The combination has been studied experimentally to model or counteract metabolic disturbances such as insulin resistance induced by elevated free fatty acids (using lipid emulsion plus heparin) and to assess whether NAC can mitigate these effects through its antioxidant action[1]. This specific triple combination does not have a unique brand name or established clinical indication but is used in research settings to study metabolic regulation.

Brand names

Intralipid

Other names

N-acetylcysteine + lipid emulsion + heparinNAC + Intralipid + heparin