N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide is a synthetic small molecule belonging to the pyrrolotriazines class. It features a fused pyrrole and triazine ring system with various substitutions. The compound is known to act as an inhibitor of mitogen‑activated protein kinase 14 (MAPK14), also known as p38 alpha MAP kinase. This enzyme plays a key role in cellular responses to stress and inflammation. The drug has been described in experimental contexts and is listed in chemical databases such as PubChem and DrugBank but does not have established clinical use or brand names at this time. Its primary mechanism involves direct inhibition of MAPK14 activity by binding to the kinase domain.[1][6]

Other names

N-Ethyl-4-{[5-(Methoxycarbamoyl)-2-Methylphenyl]amino}-5-Methylpyrrolo[2,1-F][1,2,4]triazine-6-CarboxamideN-ethyl-4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamidePyrrolo[2,1-f][1,2,4]triazine-6-carboxamide N-ethyl 4 [[5 [(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-