n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid

N-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH) is a synthetic small molecule belonging to the class of benzenesulfonamide-derived hydroxamic acids. It acts as a broad-spectrum, cell-permeable inhibitor of matrix metalloproteinases (MMPs), particularly targeting MMPs such as MMP‑3 (stromelysin‑1), MMP‑8, MMP‑9, MMP‑12, and MMP‑13. By chelating the catalytic zinc ion in the active site of these metalloenzymes, it blocks their proteolytic activity. This compound is primarily used in research settings to study the biological roles of various matrix metalloproteinases in processes like tissue remodeling and disease pathogenesis[1][2][10].

Other names

n-isobutyl-n-(4-methoxyphenylsulfonyl)glycyl hydroxamic acidN-hydroxy-2-[N-(2-methylpropyl)4-methoxybenzenesulfonamido]acetamideN-hydroxy-2-(N-(2-methylpropyl)4-methoxybenzenesulfonamido)acetamideAcetamide, N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-N-Hydroxy-N~2~-isobutyl-N~2~-[(4-methoxyphenyl)sulfonyl]glycinamide