Drug intelligence / Profile preview

n-methyl-4-(diethyldithiocarbamoyl)cyclophosphamide

Development stage
Unknown
Modality
Small Molecules
01

Overview

n-methyl-4-(diethyldithiocarbamoyl)cyclophosphamide is a synthetic derivative of cyclophosphamide, likely designed for research into modifications of classic alkylating agents. The structure indicates it is a modified nitrogen mustard, structurally related to cyclophosphamide, which is a prodrug that is metabolized in the liver to active cytotoxic metabolites that alkylate DNA and inhibit replication and transcription, leading to cell death. No evidence of clinical use, commercial development, or established mechanism of action for this exact derivative is found in current biomedical or chemical literature. Its mechanism, where relevant, would be expected to mirror that of other phosphoramide mustards unless a unique property is established.

02

Targets

N7-G (DNA guanine-N7 adduct)

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