N-palmitoylethanolamine + N-acetylethanolamine

N-palmitoylethanolamine (PEA) and N-acetylethanolamine are endogenous fatty acid amides belonging to the N-acylethanolamine family. PEA is a lipid mediator with anti-inflammatory, analgesic, neuroprotective, and antiallergic properties. Its primary mechanism of action is activation of the peroxisome proliferator-activated receptor alpha (PPAR-α), leading to downregulation of inflammatory processes and mast cell activity. PEA also interacts with GPR55 and GPR119 receptors but does not bind directly to classical cannabinoid receptors CB1 or CB2. N-acetylethanolamine shares structural similarity as an N-acylethanolamine but its specific pharmacological actions are less well characterized compared to PEA. The combination has been studied for dermatological conditions such as asteatotic eczema, where it demonstrated efficacy in reducing symptoms in clinical trials[3]. Both compounds are rapidly metabolized by enzymes such as fatty acid amide hydrolase (FAAH) and N-acylethanolamine-hydrolyzing acid amidase (NAAA)[1][6]. These agents are typically considered dietary supplements rather than pharmaceuticals in most jurisdictions.

Other names

palmitoylethanolamide + acetylethanolamide