Drug intelligence / Profile preview

nab-paclitaxel + bevacizumab + lobaplatin

Development stage
Preclinical
Lead developer
Roche
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

This is a combination therapy consisting of three components: - **Nab-paclitaxel**: A 130-nm albumin-bound formulation of paclitaxel that can enhance drug delivery to tumors and increase intra-tumor drug concentration compared to solvent-based paclitaxel. It also minimizes hypersensitivity reactions due to the absence of solvents. - **Bevacizumab**: An anti-VEGF monoclonal antibody that targets angiogenesis. - **Lobaplatin**: A platinum-based chemotherapeutic agent. While combinations of nab-paclitaxel and bevacizumab (sometimes with carboplatin) have been studied in various cancers including non-small cell lung cancer (NSCLC) and triple-negative metastatic breast cancer, the specific combination with lobaplatin is not well documented in the provided information.

02

Targets

TUBB (Tubulin (alpha and beta subunits))VEGFA (Vascular endothelial growth factor A)DNA

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