nalbuphine + propofol

Nalbuphine + propofol is a combination drug used primarily for anesthesia and sedation, especially in procedures such as gastrointestinal endoscopy, hysteroscopy, and pediatric painless colonoscopy. Nalbuphine is an opioid receptor agonist-antagonist that mainly acts as a kappa-opioid receptor agonist and partial mu-opioid receptor antagonist, providing effective analgesia with fewer side effects like respiratory depression compared to traditional opioids. Propofol is a short-acting intravenous anesthetic agent with sedative-hypnotic properties but lacks analgesic effects. The combination allows for reduced doses of propofol while maintaining adequate anesthesia depth and minimizing adverse reactions such as respiratory depression and injection pain. This combination has been shown to improve safety profiles in elderly patients, children, and those undergoing endoscopic submucosal dissection or hysteroscopic surgery[1][2][3][4][5].

Other names

纳布啡复合丙泊酚丙泊酚联合纳布啡