Drug intelligence / Profile preview

naphazoline + mepyramine + dexpanthenol

Development stage
Unknown
Lead developer
EMS
Modality
Small Molecules
Administration
Intranasal
01

Overview

Naphazoline + mepyramine + dexpanthenol is a fixed-dose combination of three small molecule drugs primarily formulated for intranasal use to treat symptoms of nasal congestion and related upper respiratory tract discomfort. - **Naphazoline** is a sympathomimetic alpha-adrenergic agonist which acts as a vasoconstrictor on mucosal blood vessels, rapidly reducing swelling and congestion. - **Mepyramine** (also known as pyrilamine) is a first-generation antihistamine acting as a histamine H1 receptor antagonist, reducing itching and other allergy symptoms. - **Dexpanthenol** is a provitamin of B5 with moisturizing and epithelial barrier-restoring properties; it protects and promotes regeneration of mucosal surfaces. This combination is used for symptomatic relief in conditions such as the common cold and rhinitis. The combination aims to provide synergistic decongestant, antihistaminic, and mucosal protective effects.

02

Targets

mAChR (Muscarinic acetylcholine receptors)ADRA1A (α1A)HRH1 (Histamine H1 Receptor)ADRA2A (α2A)NaV (Voltage-gated sodium channels)

Beyond the preview

Go deeper on naphazoline + mepyramine + dexpanthenol.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on naphazoline + mepyramine + dexpanthenol.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call