naproxen + loratadine

**Naproxen + loratadine** is a combination of two small-molecule drugs: naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and alleviate pain and inflammation, and loratadine, a second-generation antihistamine that selectively blocks peripheral histamine H1 receptors to mitigate allergic responses. This pairing has been investigated primarily for preventing bone pain associated with pegfilgrastim administration during chemotherapy, with clinical studies like the phase 2 NOLAN trial showing reduced patient-reported pain scores compared to no prophylaxis, particularly for loratadine due to its better tolerability profile. Naproxen is typically dosed at 500 mg twice daily, and loratadine at 10 mg once daily, administered orally for short durations.