Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
naproxen + PH-797804
- Development stage
- Phase 2
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Naproxen + PH-797804 is a combination of two small molecule drugs investigated for the treatment of osteoarthritis and pain. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reversibly inhibiting cyclooxygenase enzymes COX-1 and COX-2 (prostaglandin-endoperoxide synthase 1 and 2), leading to decreased prostaglandin synthesis and thus reducing inflammation and pain[1][6][8]. PH-797804 is an investigational selective inhibitor of p38 mitogen-activated protein kinase (MAPK), an enzyme involved in inflammatory signaling pathways. The combination was studied in clinical trials to assess whether dual inhibition of these targets could provide enhanced pain relief in osteoarthritis compared to either agent alone[2][4].
- Brand names
- Naproxen Sodium DS
- Other names
- naproxen
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MAPK14 (p38 mitogen-activated protein kinase alpha)
Beyond the preview
Go deeper on naproxen + PH-797804.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on naproxen + PH-797804.