naproxen + PH-797804

Naproxen + PH-797804 is a combination of two small molecule drugs investigated for the treatment of osteoarthritis and pain. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reversibly inhibiting cyclooxygenase enzymes COX-1 and COX-2 (prostaglandin-endoperoxide synthase 1 and 2), leading to decreased prostaglandin synthesis and thus reducing inflammation and pain[1][6][8]. PH-797804 is an investigational selective inhibitor of p38 mitogen-activated protein kinase (MAPK), an enzyme involved in inflammatory signaling pathways. The combination was studied in clinical trials to assess whether dual inhibition of these targets could provide enhanced pain relief in osteoarthritis compared to either agent alone[2][4].

Brand names

Naproxen Sodium DS

Other names

naproxen