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navocaftor + ABBV-576
- Development stage
- Unknown
- Lead developer
- AbbVie
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Navocaftor + ABBV-576** is an investigational oral combination therapy under development for the treatment of cystic fibrosis, typically administered with galicaftor. Navocaftor and ABBV-576 are small molecule CFTR (cystic fibrosis transmembrane conductance regulator) modulators, designed to improve the function of the defective CFTR protein in people with cystic fibrosis, particularly those who are homozygous or heterozygous for the F508del mutation. This combination acts by targeting and modulating CFTR protein activity, aiming to alleviate the symptoms and progression of cystic fibrosis. Trials have investigated the safety, pharmacokinetics, and efficacy of this regimen, especially in combination with other CFTR modulators like galicaftor[1][3][4][5][6][7][9].
- Other names
- navocaftor + ABBV-576
02
Targets
CFTR (Cystic fibrosis transmembrane conductance regulator)
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