nebivolol + amlodipine

**nebivolol + amlodipine** is a combination pharmaceutical drug indicated primarily for the treatment of *hypertension* (high blood pressure)[1][2][3][5]. It contains **nebivolol** (a third-generation cardioselective beta-1 adrenergic receptor blocker) and **amlodipine** (a dihydropyridine calcium channel blocker)[2][3][4][6]. Nebivolol exerts its antihypertensive effect by blocking beta-1 adrenergic receptors in the heart, lowering heart rate and contractility, while also increasing nitric oxide release to induce vasodilation and improve endothelial function[4][6]. Amlodipine inhibits L-type calcium channels in vascular smooth muscle, preventing calcium influx, thereby relaxing arterial muscle, dilating peripheral arterioles, and lowering peripheral vascular resistance[4][6]. The combination provides complementary mechanisms, resulting in significant reductions in *central and peripheral blood pressure* and *arterial stiffness*, with generally minor and tolerable side effects—particularly advantageous for patients who do not tolerate traditional beta-blockers or require multiple antihypertensives[3][5].

Brand names

Nebilong AM

Other names

amlodipine + nebivololAmlodipine/Nebivololnebivolol/amlodipine combination