neomycin + metronidazole + polyethylene glycol

This **combination** is used as an oral preoperative regimen to prepare the bowel before elective colorectal surgery. It combines **neomycin** (an aminoglycoside antibiotic targeting aerobic bacteria), **metronidazole** (an antibiotic primarily effective against anaerobic bacteria), and **polyethylene glycol** (a non-absorbable osmotic laxative that induces mechanical bowel evacuation). The antibiotics reduce colonic bacterial load, minimizing perioperative infection risk, while polyethylene glycol flushes the colon, enhancing the effect. This regimen is adopted widely in surgical protocols and is supported by clinical studies showing a significant reduction in surgical site infections and post-operative complications when used together for preoperative bowel preparation[1][2][3][5][7][8][9][10].

Other names

MOABPMechanical and oral antibiotic bowel preparation