Drug intelligence / Profile preview

Neomycin + Polymyxin B sulfate + Bacitracin zinc + Hydrocortisone acetate

Development stage
Approved
Lead developer
Sandoz
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Antimicrobial Peptides → Native Peptides → Peptides
Administration
Ophthalmic
01

Overview

This combination includes antibiotics (neomycin, polymyxin B sulfate, bacitracin zinc) and a corticosteroid (hydrocortisone acetate). It is used to treat steroid-responsive inflammatory ocular conditions where bacterial infection or risk of infection exists. Neomycin and polymyxin B sulfates are active against a wide range of bacteria, including **Staphylococcus aureus**, **Streptococcus pneumoniae**, **Escherichia coli**, **Haemophilus influenzae**, **Klebsiella/Enterobacter** species, **Neisseria** species, and **Pseudomonas aeruginosa**. Bacitracin zinc also contributes to its antimicrobial activity. Hydrocortisone acetate reduces inflammation by suppressing the immune response. - **mechanisms**: The antibiotics work by inhibiting bacterial protein synthesis or disrupting cell membranes, while hydrocortisone acetate reduces inflammation by modulating immune responses.

Brand names
Fougera and Co.
02

Targets

Bacterial RibosomeLipid AGR (Glucocorticoid receptor)C55-PP (Undecaprenyl pyrophosphate)Neuraminidase

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