Drug intelligence / Profile preview

neomycin + thiostrepton + triamcinolone acetonide

Development stage
Unknown
Lead developer
Dechra Veterinary Products
Modality
Cyclic Peptides → Modified Peptides → Peptides, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, RNA-Targeting Small Molecules → Nucleic Acid-Directed Small Molecules → Small Molecules, Antimicrobial Peptides → Native Peptides → Peptides
Administration
Topical, Otic
01

Overview

This is a veterinary topical combination drug containing neomycin (an aminoglycoside antibiotic), thiostrepton (a cyclic oligopeptide antibiotic), and triamcinolone acetonide (a synthetic corticosteroid). It is most commonly formulated with nystatin as well. The combination provides broad-spectrum antibacterial activity (neomycin and thiostrepton), anti-inflammatory and antipruritic effects (triamcinolone acetonide), and antifungal action when nystatin is present. The ointment is indicated for the treatment of acute and chronic otitis, interdigital cysts in cats and dogs, anal gland infections in dogs, as well as various dermatologic disorders characterized by inflammation or dermatitis—especially those complicated or threatened by bacterial or fungal infections. Its mechanism of action includes inhibition of bacterial protein synthesis (neomycin/thiostrepton) and suppression of inflammatory responses via glucocorticoid receptor agonism (triamcinolone). This product is approved for use in animals only[1][2][3][4].

Brand names
AnimaxDermalonePanalogDerma-Vet
Other names
nystatin + neomycin sulfate + thiostrepton + triamcinolone acetonide ointment
02

Targets

GR (Glucocorticoid receptor)GAC (Group A carbohydrate antigen)30S A-site (Bacterial ribosomal 30S A-site)

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