neomycin sulfate + polymyxin b sulfate + hydrocortisone

neomycin sulfate + polymyxin b sulfate + hydrocortisone is a combination pharmaceutical product for topical use, most commonly as otic drops, containing **two antibiotics** (neomycin sulfate, polymyxin b sulfate) and **one corticosteroid** (hydrocortisone)[1][2][6]. - **Neomycin sulfate** is an aminoglycoside antibiotic, **polymyxin b sulfate** is a polypeptide antibiotic—both work by inhibiting bacterial protein synthesis (neomycin) and disrupting bacterial cell membranes (polymyxin B), respectively[2][6]. - **Hydrocortisone** is a synthetic corticosteroid that reduces inflammation, swelling, redness, and itching[1][2][6]. The **primary indication** is superficial bacterial infections of the external auditory canal (outer ear infections), including those that may occur after ear surgeries such as mastoidectomy[1][2][6]. This combination is not appropriate for all bacterial infections due to possible resistance, and should not be used if there is a hole or tear in the eardrum[6]. **Formulated as** both a solution and a suspension for otic use (ear drops), each mL typically contains: neomycin sulfate (equivalent to 3.5 mg neomycin base), polymyxin b sulfate (equivalent to 10,000 polymyxin b units), and hydrocortisone (10 mg/1%)[3][6]. **Prescribed only** under medical supervision and for short-term use[1][6]. **Common side effects** include local irritation and, rarely, allergic reactions such as rash, swelling, or hearing loss (ototoxicity)[6]. **Not recommended** for viral, fungal, or mycobacterial infections, or if there is known hypersensitivity to any component[3].

Brand names

Casporyn HCCortisporinCortomycinOti-SonePedioticAntibiotic OticOticair

Other names

neomycin/polymyxin b/hydrocortisoneneomycin+polymyxin b+hydrocortisoneneomycin polymyxin hydrocortisone otictriple antibiotic + steroid oticneomycin sulfate+polymyxin b sulfate+hydrocortisone otic solution/suspension