Neomycin sulphate + Bacitracin zinc

Based on the search results, I'll provide comprehensive information about neomycin sulphate + bacitracin zinc. Neomycin sulphate + bacitracin zinc is a combination antibiotic medication primarily used for topical application. This combination is often formulated with polymyxin B as a triple antibiotic preparation for treating or preventing superficial bacterial infections. ## Composition and Formulation The medication typically contains: - Neomycin sulphate (also spelled sulfate): An aminoglycoside antibiotic - Bacitracin zinc: A polypeptide antibiotic These active ingredients are usually formulated in an ointment base, commonly white petrolatum or mineral oil for topical application[1][2]. ## Mechanism of Action This combination provides a wide spectrum of antibacterial activity through complementary mechanisms: - **Neomycin sulphate**: Bactericidal for many gram-positive and gram-negative organisms. It inhibits protein synthesis by binding with ribosomal RNA and causing misreading of the bacterial genetic code[4]. - **Bacitracin zinc**: Bactericidal for various gram-positive and gram-negative organisms. It interferes with bacterial cell wall synthesis by inhibiting the regeneration of phospholipid receptors involved in peptidoglycan synthesis[4]. ## Clinical Uses The combination is indicated for: 1. Prevention of superficial bacterial skin infections associated with minor cuts, scrapes, or burns[5][9]. 2. Treatment of minor skin infections caused by susceptible bacteria[3][5]. 3. When formulated with polymyxin B, it's used for topical treatment of superficial infections of the external eye and its adnexa[4][8]. ## Microbial Coverage The combination is effective against numerous bacteria including: - Staphylococcus aureus - Streptococci (including Streptococcus pneumoniae) - Escherichia coli - Haemophilus influenzae - Klebsiella-Enterobacter species - Neisseria species - Pseudomonas aeruginosa[4][6] ## Administration The medication is applied topically to the affected area, typically 1-3 times daily or as directed by a healthcare provider[3]. For ophthalmic formulations, specific instructions for eye application must be followed[4][8]. ## Contraindications The medication is contraindicated in: - Individuals with hypersensitivity to any of the components - For ophthalmic formulations: viral diseases of the cornea and conjunctiva, mycobacterial infections, and fungal diseases of ocular structures[6] - Not for injection into the eye or for use in the external ear canal if the eardrum is perforated[5][6] ## Precautions - For external use only - Avoid contact with eyes (for skin formulations) - Prolonged use may lead to overgrowth of non-susceptible organisms - Discontinue use if irritation or hypersensitivity reactions occur[2][5] This combination antibiotic provides effective broad-spectrum coverage for superficial bacterial infections and is available in various formulations for different clinical applications.

Other names

Neomycin sulfate + Bacitracin zinc