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nepeta menthoides boiss. & buhse
- Development stage
- Phase 3
- Lead developer
- Shiraz University of Medical Sciences
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
*Nepeta menthoides* Boiss. & Buhse is a medicinal plant in the Lamiaceae family, native to Iran, where it is traditionally known as Ustukhuddus-e-Nuri in Persian medicine. It is primarily utilized for its sedative, anxiolytic, and antidepressant properties. Clinical research, notably conducted by the Shiraz University of Medical Sciences, has evaluated freeze-dried extracts of the plant in randomized controlled trials for the treatment of anxiety and depression, often comparing its efficacy to standard pharmaceuticals like sertraline. The plant's pharmacological activity is attributed to various secondary metabolites, including nepetalactones and flavonoids, which are thought to modulate the GABAergic system to produce calming effects.
- Other names
- Nepeta menthoidesNepeta menthoides Boiss. & BuhseUstukhuddus-e-Nuri
02
Targets
GABRR (GABA-A receptor subunit rho)
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