neuropeptide y (3-36)

Neuropeptide Y (3-36) is an N-terminally truncated analog of the endogenous 36-amino acid peptide Neuropeptide Y (NPY). It is naturally formed through the cleavage of NPY (1-36) by the enzyme dipeptidyl peptidase-4 (DPP-4). Unlike the full-length peptide, NPY (3-36) is a selective agonist for the Y2 and Y5 receptor subtypes and lacks significant activity at the Y1 receptor, which is responsible for mediating vasoconstriction. In ophthalmic research, specifically for the treatment of glaucoma, NPY (3-36) is being investigated for its ability to provide neuroprotection to retinal ganglion cells and preserve axonal integrity. By bypassing Y1-mediated vascular complications, it offers a safer profile for intraocular administration. Its therapeutic effects are associated with the activation of PI3K/Akt survival signaling and the suppression of neuroinflammatory responses in astrocytes and microglia.

Other names

N-terminally truncated neuropeptide YNPY 3-36NPY3-36NPY-3-36