nevirapine + fluconazole

**Nevirapine + fluconazole** is a combination of two small-molecule pharmaceutical drugs: **nevirapine**, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used primarily in antiretroviral therapy for HIV-1 infection, and **fluconazole**, a triazole antifungal agent used to treat and prevent fungal infections. When co-administered, fluconazole inhibits cytochrome P450 enzymes (notably CYP3A4 and CYP2B6), which results in reduced hepatic metabolism of nevirapine, leading to a significant increase in nevirapine plasma concentrations. While fluconazole’s effect on nevirapine efficacy is pharmacokinetic rather than pharmacodynamic, this interaction increases the risk of nevirapine-related adverse events, particularly hepatotoxicity and, less commonly, rash. This combination is sometimes used in the context of HIV/AIDS, especially where antifungal prophylaxis or treatment is required simultaneously with antiretroviral therapy[1][2][3][4].