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nevirapine + lamivudine
- Development stage
- Phase 4
- Lead developer
- Boehringer Ingelheim
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a **combination antiretroviral therapy** consisting of the drugs **nevirapine** and **lamivudine**. Nevirapine is classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI), while lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI). This combination is used in the management of **HIV-1 infection** as part of highly active antiretroviral therapy (HAART). Both drugs act by inhibiting the reverse transcriptase enzyme, which is essential for the replication of HIV. The combination can be used with an additional NRTI, such as zidovudine or stavudine, to form a complete regimen. Nevirapine binds directly to reverse transcriptase and blocks the RNA-dependent and DNA-dependent DNA polymerase activities, while lamivudine is incorporated into viral DNA by reverse transcriptase, resulting in chain termination.
- Other names
- nevirapine + lamivudine
02
Targets
Human immunodeficiency virus type 1 reverse transcriptaseHIV-2 reverse transcriptaseHBV Pol (Hepatitis B virus polymerase)
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