Drug intelligence / Profile preview

nevirapine + nelfinavir + stavudine

Development stage
Phase 2
Lead developer
Boehringer Ingelheim
Modality
Small Molecules
Administration
Oral
01

Overview

A combination of three antiretroviral drugs: **nevirapine** (a non-nucleoside reverse transcriptase inhibitor), **nelfinavir** (an HIV-1 protease inhibitor), and **stavudine** (a nucleoside reverse transcriptase inhibitor) used together as part of highly active antiretroviral therapy (HAART) for the treatment of HIV-1 infection. This combination is studied for its efficacy and safety in suppressing HIV replication, with each component targeting different steps of the viral life cycle. Nevirapine and stavudine inhibit reverse transcriptase, thereby blocking viral RNA to DNA conversion, while nelfinavir inhibits HIV protease, blocking viral protein maturation[3].

02

Targets

PR (Progesterone receptor)Human immunodeficiency virus type 1 reverse transcriptase

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