nevirapine + prednisone

Nevirapine + prednisone is a combination of two drugs: nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used as an antiretroviral agent against HIV-1, and prednisone, a synthetic glucocorticoid corticosteroid with anti-inflammatory and immunosuppressive properties. This combination has been studied primarily for the prevention or management of nevirapine-associated rash in patients initiating antiretroviral therapy. Clinical trials have shown that short-term prednisone administration does not decrease— and may increase—the risk or severity of rash caused by nevirapine initiation, and thus is not recommended for this use[1][4][5]. There are no approved indications for this combination as a fixed therapeutic regimen. Nevirapine acts by inhibiting the reverse transcriptase enzyme, blocking viral replication, while prednisone acts via the glucocorticoid receptor, exerting broad anti-inflammatory effects.