Drug intelligence / Profile preview

newcastle disease and infectious bronchitis vaccine, live, thermotolerant

Development stage
Unknown
Lead developer
Indian Veterinary Research Institute
Modality
Vaccines & Immunotherapeutics
Administration
Intranasal, Ophthalmic
01

Overview

This is a bivalent, live-attenuated veterinary vaccine designed to protect poultry against Newcastle Disease (ND) and Infectious Bronchitis (IB). The vaccine incorporates a thermotolerant stabilizer, which allows the product to maintain potency at ambient temperatures, significantly reducing the reliance on a strict cold chain during distribution in tropical or resource-limited regions. Newcastle Disease is caused by virulent strains of avian paramyxovirus type 1 (Newcastle disease virus), while Infectious Bronchitis is caused by an avian coronavirus (Infectious bronchitis virus). The vaccine typically utilizes attenuated strains such as LaSota for the ND component and H120 for the IB component. It is primarily administered to chickens via intraocular, intranasal, or drinking water routes to stimulate mucosal and systemic immunity.

Other names
bivalent live vaccine for newcastle disease and infectious bronchitis + thermotolerant stabilizerND+IB thermotolerant vaccinethermostable ND-IB vaccineNewcastle disease and infectious bronchitis vaccine, live, thermostable
02

Targets

alpha2,3-SA (alpha2,3-linked sialic acid receptor)Sialoglycan (Cell-surface sialoglycan)

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