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nezastomig + REGN4336
- Development stage
- Phase 2
- Lead developer
- Regeneron Pharmaceuticals
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Nezastomig + REGN4336 is an investigational combination immunotherapy being developed by Regeneron Pharmaceuticals for the treatment of metastatic castration-resistant prostate cancer (mCRPC). The regimen consists of two bispecific antibodies: nezastomig (REGN5678), which targets PSMA and CD28 to provide costimulatory 'Signal 2' to T-cells, and REGN4336, which targets PSMA and CD3 to provide the primary activation 'Signal 1'. By simultaneously engaging both receptors on T-cells and targeting the prostate-specific membrane antigen (PSMA) on tumor cells, this combination is designed to enhance T-cell proliferation and cytotoxic activity against prostate cancer cells while potentially improving the safety profile compared to high-dose CD3-bispecific monotherapy.
- Other names
- nezastomig + REGN4336
02
Targets
CD28 (Cluster of Differentiation 28)CD3 (T-cell surface glycoprotein CD3)PSMA (Prostate-specific membrane antigen)
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