Drug intelligence / Profile preview

niacin extended-release + lovastatin

Development stage
Approved
Lead developer
Abbott
Modality
Small Molecules
Administration
Oral
01

Overview

**Niacin extended-release + lovastatin** is an oral fixed-dose lipid-modifying combination formerly marketed in the United States as **Advicor**. It combines extended-release niacin, which lowers triglycerides and can raise HDL cholesterol, with lovastatin, an HMG-CoA reductase inhibitor that reduces hepatic cholesterol synthesis and increases LDL clearance. Advicor was approved for primary hypercholesterolemia and mixed dyslipidemia as an adjunct to diet. FDA withdrew its NDA approval effective April 18, 2016, after determining that it had been withdrawn from sale for reasons of safety and effectiveness. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=dbdee4c0-86fa-4857-b536-79bf9ebb911a))

Brand names
Advicor
Other names
extended-release niacin + lovastatinlovastatin + niacin extended-releaseniacin ER/lovastatinniacin extended release + lovastatinniacin extended-release/lovastatinniacin/lovastatin
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)HCAR2 (Hydroxycarboxylic acid receptor 2)

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