niacinamide + retinol

Niacinamide + retinol is a synergistic topical combination widely utilized in dermatology and cosmeceuticals for the management of photoaging, acne, and hyperpigmentation. Retinol, a precursor to retinoic acid, acts as a retinoic acid receptor (RAR) agonist, promoting keratinocyte proliferation, enhancing epidermal thickness, and stimulating collagen synthesis. However, its use is frequently limited by 'retinization,' a period of skin irritation characterized by erythema and dryness. Niacinamide (vitamin B3) serves as a precursor to the cofactors NAD+ and NADP+, which are essential for cellular energy metabolism and DNA repair. Niacinamide enhances the skin's barrier function by increasing the synthesis of ceramides and other stratum corneum lipids, while also providing potent anti-inflammatory effects. When formulated together, niacinamide mitigates the irritant potential of retinol, improving patient tolerability and overall therapeutic efficacy in improving skin texture and tone.

Brand names

Olay Regenerist Retinol 24La Roche-Posay Retinol B3CeraVe Resurfacing Retinol SerumPaula's Choice Clinical 0.3% Retinol + 2% Bakuchiol TreatmentSkinCeuticals Retinol 0.3

Other names

nicotinamide + retinolvitamin B3 + vitamin Aniacinamide and retinol combination