niacinamide + saccharide isomerate

Niacinamide + saccharide isomerate is a topical cosmetic/dermatologic combination of vitamin B3 (niacinamide) with a carbohydrate complex humectant (saccharide isomerate) designed primarily for skin hydration, barrier support, and soothing. Niacinamide reduces transepidermal water loss, improves barrier lipid synthesis, and has anti-inflammatory and tone-evening effects, while saccharide isomerate mimics the skin’s natural moisturizing factor to bind water in the stratum corneum and provide long-lasting hydration and barrier reinforcement.[1][2] This combination is used in moisturizers, serums, and acne- or brightening-focused skincare products to support barrier repair, decrease dryness and irritation, and enhance overall skin smoothness and suppleness.[1][2][5][6]