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niacinamide + zinc sulfate + copper
- Development stage
- Unknown
- Lead developer
- DUSA Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
niacinamide + zinc sulfate + copper is an oral combination therapy primarily utilized for the management of inflammatory dermatological conditions, including acne vulgaris and rosacea. Niacinamide, a form of vitamin B3, exerts potent anti-inflammatory effects by inhibiting poly(ADP-ribose) polymerase-1 (PARP-1) and reducing the production of pro-inflammatory cytokines such as IL-8 and TNF-alpha. Zinc sulfate serves as an antimicrobial and anti-inflammatory agent, helping to reduce sebum production and inhibit the growth of *Cutibacterium acnes* (formerly *Propionibacterium acnes*). Copper is included in the formulation to mitigate the risk of zinc-induced copper deficiency, a potential side effect of long-term zinc supplementation. This combination is frequently classified as a medical food or prescription dietary supplement in the United States.
- Brand names
- NicomideNicAzelAzellex
- Other names
- Vitamin B3 + Zinc + CopperNicotinamide + Zinc Sulfate + Copper
02
Targets
PARP1 (Poly (adp-ribose) polymerase 1)
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