Drug intelligence / Profile preview

nicotine patch + nicotine gum + nicotine inhaler

Development stage
Unknown
Lead developer
Johnson & Johnson
Modality
Small Molecules
Administration
Transdermal, Oral, Inhalation
01

Overview

This is a combination of three forms of nicotine replacement therapy (NRT): the transdermal nicotine patch (e.g., Nicoderm CQ), oral nicotine gum (e.g., Nicorette), and the prescription-only nicotine inhaler (e.g., Nicotrol Inhaler). The patch provides a steady, long-acting baseline level of nicotine throughout the day by absorption through the skin. The gum and inhaler are short-acting forms that deliver rapid relief from cravings by providing additional doses of nicotine as needed. This multi-modal approach targets both continuous withdrawal symptoms and acute cravings, improving smoking cessation rates compared to monotherapy. All three products act as agonists at nicotinic acetylcholine receptors in the brain, reducing withdrawal symptoms and cigarette cravings without exposing users to harmful tobacco smoke constituents[1][3][4][5][6].

Brand names
Nicoderm CQNicoretteNicotrol Inhaler
Other names
combination nicotine replacement therapyNRT combination therapypatch plus gum plus inhaler
02

Targets

CHRNA7 (α7 nicotinic receptor)α4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)

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