Drug intelligence / Profile preview

Nicotine patch + nicotine lozenge

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Transdermal, Oral
01

Overview

Nicotine patch + nicotine lozenge is a combination of two forms of nicotine replacement therapy (NRT) used to aid in smoking cessation. Both deliver controlled amounts of pharmaceutical-grade nicotine to reduce withdrawal symptoms and cravings associated with quitting tobacco. The transdermal patch provides a steady release of nicotine through the skin over 16–24 hours, while the oral lozenge delivers rapid relief by dissolving in the mouth and allowing absorption through the oral mucosa. This dual approach targets both baseline withdrawal and acute cravings. The primary indication is for smoking cessation in adults[2][3][4][5]. Mechanistically, both products act as agonists at nicotinic acetylcholine receptors to substitute for tobacco-derived nicotine and mitigate dependence-related symptoms.

Brand names
NicoretteNicoreliefLeader Nicotine PolacrilexThriveNic Nac
Other names
nicotine polacrilex
02

Targets

α4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)α6β2 nAChR (α6β2 nicotinic receptor)

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