nifedipine + theophylline

This is a combination drug consisting of nifedipine and theophylline. Nifedipine is a calcium channel blocker primarily used to treat hypertension and angina, while theophylline is a xanthine derivative bronchodilator used for asthma and other chronic lung diseases. The combination has been studied in patients with asthma to assess potential pharmacokinetic interactions and clinical effects. Nifedipine acts by inhibiting L-type calcium channels, leading to vasodilation, while theophylline relaxes bronchial smooth muscle through phosphodiesterase inhibition (increasing cAMP) and adenosine receptor antagonism, resulting in bronchodilation. Studies indicate that co-administration may alter serum levels of theophylline over time but generally does not significantly impact clinical outcomes such as peak expiratory flow rate or symptom control in asthma patients[1][2][3][6].