nimesulide + cetirizine

Onimex CZ is a combination pharmaceutical product developed and marketed by Emcee Pharmaceuticals, primarily available in the Indian market. It is formulated as a tablet containing nimesulide, a non-steroidal anti-inflammatory drug (NSAID), and cetirizine, a second-generation antihistamine. Nimesulide acts as a preferential inhibitor of cyclooxygenase-2 (COX-2), which reduces the synthesis of prostaglandins responsible for pain, fever, and inflammation. Cetirizine functions as a potent and selective antagonist of peripheral histamine H1 receptors, providing relief from allergic symptoms such as sneezing, rhinorrhea, and pruritus. This combination is typically indicated for the symptomatic management of inflammatory conditions accompanied by allergic manifestations, including the common cold, sinusitis, and upper respiratory tract infections. While nimesulide is restricted in several global markets due to concerns regarding hepatotoxicity, it remains a commonly prescribed analgesic for adults in India.

Brand names

Onimex CZ