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nimotuzumab + adebrelimab + albumin-bound paclitaxel + carboplatin
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
This combination therapy is being evaluated in a Phase Ib/II clinical trial led by Fudan University for the treatment of recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) in patients who are ineligible for high-dose cisplatin. The regimen consists of nimotuzumab, a humanized monoclonal antibody targeting the epidermal growth factor receptor (EGFR); adebrelimab, a humanized monoclonal antibody targeting programmed death-ligand 1 (PD-L1); and a chemotherapy backbone of albumin-bound paclitaxel and carboplatin. By combining EGFR inhibition, immune checkpoint blockade, and cytotoxic chemotherapy, the regimen aims to provide a synergistic anti-tumor effect while offering a more tolerable alternative for cisplatin-ineligible patients.
- Other names
- Nimotuzumab + Adebrelimab + ChemotherapyNimotuzumab + Adebrelimab + nab-paclitaxel + carboplatin
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)TUBB (Tubulin (alpha and beta subunits))CD274 (Programmed cell death protein 1 ligand 1)DNA
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