Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
nirogacestat + rabeprazole
- Development stage
- Phase 1
- Lead developer
- SpringWorks Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a combination of **nirogacestat** (a small molecule gamma secretase inhibitor mainly used in desmoid tumors) and **rabeprazole** (a proton pump inhibitor used for acid-related gastrointestinal diseases). Nirogacestat inhibits gamma secretase and thereby blocks activation of the Notch receptor, impeding tumor growth. Rabeprazole suppresses gastric acid secretion by irreversible inhibition of the gastric proton pump H+/K+ ATPase. The combination has been studied in a phase 1 setting to evaluate pharmacokinetic and safety interactions, with specific relevance for the impact of gastric acid suppression on nirogacestat absorption and exposure[1][4][5].
- Brand names
- Ogsiveo + rabeprazole
- Other names
- nirogacestat + rabeprazole
02
Targets
GSEC (Gamma-Secretase Complex)NOTCH (Neurogenic locus notch homolog protein 3)ATP4A (Potassium–transporting ATPase alpha chain 1)
Beyond the preview
Go deeper on nirogacestat + rabeprazole.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on nirogacestat + rabeprazole.