nitrendipine + hydrochlorothiazide

Nitrendipine + hydrochlorothiazide is a fixed-dose combination of two antihypertensive agents used for the treatment of hypertension. Nitrendipine is a dihydropyridine calcium channel blocker that acts as a peripheral vasodilator by inhibiting the influx of extracellular calcium across myocardial and vascular smooth muscle cell membranes, leading to decreased vascular resistance and blood pressure[5][8]. Hydrochlorothiazide is a thiazide diuretic that reduces blood pressure by increasing renal excretion of sodium and water, thereby decreasing plasma volume[2][3][4]. The combination provides additive antihypertensive effects compared to either agent alone, making it effective in patients who require more than one medication to achieve blood pressure control[8].