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nitroglycerin + acetazolamide
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral (acetazolamide), Intravenous (both Drugs Individually), Sublingual (nitroglycerin), Transdermal (nitroglycerin), Topical (nitroglycerin)
01
Overview
This is a combination of two small molecule drugs, nitroglycerin and acetazolamide. Nitroglycerin is an organic nitrate vasodilator primarily used to treat angina pectoris and heart failure by releasing nitric oxide, which relaxes vascular smooth muscle and dilates blood vessels. Acetazolamide is a carbonic anhydrase inhibitor used as a diuretic, anticonvulsant, antiglaucoma agent, and for the prevention of altitude sickness; it works by inhibiting carbonic anhydrase in the proximal renal tubule, leading to increased excretion of sodium bicarbonate and water. The combination has been studied experimentally for its effects on cerebral blood flow; evidence suggests that when administered together, the increase in cerebral blood flow is mainly attributed to acetazolamide rather than nitroglycerin[1][2]. There are no approved fixed-dose combination products containing both agents.
- Other names
- GTN + acetazolamidenitroglycerin + acetazolamideGTN + Diamoxglyceryl trinitrate + azetazolamide-Danish Headache Center
02
Targets
CA2 (Carbonic Anhydrase 2)sGC (Soluble Guanylyl Cyclase)
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