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NK1R+ mesenchymal stem cells
- Development stage
- Unknown
- Lead developer
- BioCardia
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous, Intracardiac
01
Overview
**NK1R+ mesenchymal stem cells** are allogeneic, culture-expanded, bone marrow-derived mesenchymal stem cells expressing the **Neurokinin-1 receptor (NK1R)**. Substance P is the primary endogenous ligand for NK1R, and this interaction is a key mediator of inflammation in organs such as the heart and lungs. NK1R+ MSC therapy is being developed for cardiovascular and pulmonary indications, including **ischemic heart failure** and **acute respiratory distress syndrome (ARDS) following Covid-19**, where anti-inflammatory and regenerative properties may provide therapeutic benefit. These cells may be delivered intravenously or directly to the heart and are manufactured from pre-screened younger donors by BioCardia. The mechanism of action centers on engagement of Substance P with NK1R on MSCs, offering effects on proliferation, differentiation, migration, and local anti-inflammatory activities[2][4][3].
- Brand names
- CardiALLO NK1R+ MSC
- Other names
- Neurokinin-1 receptor-positive mesenchymal stem cellsNeurokinin1 receptor-positive mesenchymal stem cellsNeurokinin 1 receptor-positive mesenchymal stem cellsNK1R+ MSCsNeurokinin 1 receptor+ MSCs
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