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NN3 (Fujian Medical Univ.)
- Development stage
- Preclinical
- Lead developer
- Fujian Medical University
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules
01
Overview
NN3 (Fujian Medical Univ.): sourced facts only. name: "Here, we investigated a PARP1 PROTAC termed "NN3″, which triggered ubiquitination and proteasome-mediated degradation of PARP1." [PMID:36309080]; target: "Here, we investigated a PARP1 PROTAC termed "NN3″, which triggered ubiquitination and proteasome-mediated degradation of PARP1." [PMID:36309080]; developer: "Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, China; Fujian Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou, China." [PMID:36309080]; modality: "we developed a proteolysis-targeted chimaera (PROTAC) to degrade mutant PARP1 in TNBC" [PMID:36309080]; stage: "Furthermore, NN3 showed potent activity and low toxicity in vivo." [PMID:36309080]
02
Targets
PARP1 (Poly (adp-ribose) polymerase 1)
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