non-G6PD deficient red blood cell-University of North Carolina, Chapel Hill-sickle cell disease

Non-G6PD deficient red blood cells refer to erythrocyte units collected from donors with normal levels of the glucose-6-phosphate dehydrogenase (G6PD) enzyme. In the management of sickle cell disease (SCD), red blood cell transfusions are a primary therapeutic intervention used to increase oxygen-carrying capacity and reduce the concentration of sickle hemoglobin (HbS). This specific biological product is utilized in clinical research, notably by the University of North Carolina at Chapel Hill (e.g., NCT02534909), to investigate whether the G6PD status of donor blood affects the survival and efficacy of transfused cells in the oxidative environment of a sickle cell patient. Because G6PD is critical for protecting erythrocytes against oxidative stress—a condition prevalent in SCD—transfusing cells with normal G6PD activity is hypothesized to result in superior post-transfusion recovery and longer cell lifespan compared to G6PD-deficient units.

Other names

Non-G6PD deficient Red Blood Cell TransfusionNon-G-6PD deficient Red Blood Cell TransfusionNon-G 6PD deficient Red Blood Cell TransfusionNormal G6PD red blood cells