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non-pegylated liposomal doxorubicin + paclitaxel + pertuzumab + trastuzumab
- Development stage
- Preclinical
- Lead developer
- Sopherion Therapeutics
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Subcutaneous
01
Overview
This is a combination therapy consisting of four distinct agents: non-pegylated liposomal doxorubicin (an anthracycline chemotherapy agent), paclitaxel (a taxane chemotherapy agent), pertuzumab and trastuzumab (both HER2-targeted monoclonal antibodies). This combination is used for the treatment of HER2-positive breast cancer. Pertuzumab and trastuzumab work by targeting different domains of the HER2 receptor, blocking cell growth and division in HER2-positive cancer cells. Paclitaxel is a taxane that disrupts microtubule function, essential for cell division. Non-pegylated liposomal doxorubicin is an anthracycline that interferes with DNA replication.
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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