Drug intelligence / Profile preview

normal saline + bupivacaine

Development stage
Unknown
Modality
Small Molecules
Administration
Intrathecal, Epidural, Local Infiltration, Perineural
01

Overview

This is a combination of normal saline (sterile 0.9% sodium chloride solution) and bupivacaine, an amide-type local anesthetic. The mixture is commonly used in clinical practice to dilute bupivacaine for spinal, epidural, or local infiltration anesthesia. Normal saline serves as a diluent to adjust the concentration and baricity of bupivacaine, allowing for tailored onset and duration of anesthesia depending on the surgical procedure. Bupivacaine acts by blocking voltage-gated sodium channels in neuronal membranes, inhibiting nerve impulse transmission and providing regional or local anesthesia[1][4][6]. This combination does not have a unique brand name but is widely used in perioperative pain management.

02

Targets

PTGER1 (Prostaglandin E Receptor 1)NaV alpha (Voltage-gated sodium channel alpha subunit family)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)

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