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normal saline + standard treatment

Development stage: Unknown
Lead developer: Pharmazz
Modality: Small Molecules
Administration: Intravenous

Overview

Normal saline + standard treatment refers to the control arm regimen used in clinical trials sponsored by Pharmazz, Inc., specifically for the treatment of hypovolemic shock. In the Phase III trial (NCT04045327), this arm serves as the comparator to the experimental resuscitative agent centhaquine (PMZ-2010). Normal saline (0.9% sodium chloride solution) acts as an isotonic crystalloid for volume expansion and as a vehicle for blinding, while "standard treatment" encompasses the standard of care for shock resuscitation, which may include intravenous fluids, blood products, and vasopressors according to established medical guidelines.

Other names: Control ArmVehicle + Standard Treatment

Targets

GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)

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