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nortriptyline + propranolol
- Development stage
- Unknown
- Lead developer
- Centaur Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Nortriptyline + propranolol is a combination medication used primarily for the prevention of migraine headaches. Nortriptyline is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine at neuronal cell membranes and blocks pain signal transmission. Propranolol is a beta blocker that slows heart rate and widens blood vessels. Clinical studies have shown that this combination is effective for migraine prevention, with safety profiles similar to monotherapy with either drug.
- Brand names
- TriptololGaltrip BetaTripbetaAmnotript-PRAmnurite BetaPro ATTryptojam-ProTriptorain-PRTriptamin PR
- Other names
- Amitriptyline + Propranolol
02
Targets
ADRB1 (β1)SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)mAChR (Muscarinic acetylcholine receptors)
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