N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide

N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide is an experimental small molecule belonging to the biphenyldicarboxamides chemical class. It has a molecular formula of C22H24N2O2 and a molecular weight of approximately 348.44 g/mol[1][2][8]. The compound has been studied as a potent inhibitor of mitogen‑activated protein kinase 14 (MAPK14/p38α), with reported IC50 and Ki values in the low nanomolar range[1]. It also shows inhibitory activity against cytochrome P450 enzymes CYP2C19 and CYP1A2 at higher concentrations[6]. There are no approved indications or clinical trials beyond preclinical/experimental stages for this compound.

Other names

N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide[1,1′-Biphenyl]-3,4′-dicarboxamide, N3-cyclopropyl-N4′-(cyclopropylmethyl)-6-methyl-515134-70-0 (CAS number)