OAC + clopidogrel

OAC + clopidogrel (double therapy) is an antithrombotic regimen that combines an oral anticoagulant (OAC) with the antiplatelet medication clopidogrel. This combination is primarily used in patients who have both atrial fibrillation (requiring anticoagulation) and coronary artery disease or who have undergone percutaneous coronary intervention (PCI)[4]. The combination aims to balance the reduction of thrombotic risk while minimizing bleeding complications. Clinical trials have shown that this double therapy approach may be preferable to triple therapy (OAC + dual antiplatelet therapy) in certain patient populations, as it can reduce bleeding events while maintaining efficacy in preventing thrombotic events[4].

Other names

double therapy (OAC + antiplatelet)